Professor Scott Kimsy (Brad Johnson) is an American geologist monitoring a local volcano when the Supergator, a Deinosuchus recreated from fossilized, preserved DNA escapes from a secret bio-engineering research center/laboratory. Along the way, it eats many people, including two lovers, three drunken teens, three models, two tourists and a fisherman. It also eats Alexandra Stevens, (Mary Stiefvater) and Ryan Houston (Josh Kelly)

Kinney joins forces with another scientist (McGillis) and a Texan alligator hunter (Colton). They pursue the monster as it heads down river intent on destroying a luxurious resort packed with hundreds of tourists. Guns and other weapons have no effect on it at all, so they plan a trap for it using a fake volcano. They lure him on to it, with the Texan alligator hunter as live bait. Supergator gets him and is blown up with poisonous gas, strong flames and a shotgun.